PHB Gene Summary [Human]
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | PHB |
| Official Name | prohibitin [Source:HGNC Symbol;Acc:HGNC:8912] |
| Ensembl ID | ENSG00000167085 |
| Bio databases IDs | |
| Aliases | prohibitin, prohibitin 1 |
| Synonyms | BAP32, HEL-215, HEL-S-54e, PHB, Prohibitin, prohibitin 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SPFH_like
- nuclear export signal
- membrane-association domain
- prohibitin homologues
- transcription co-repressor
- G-protein-coupled receptor binding
- enzyme binding
- histone deacetylase binding
- protein binding
- SPFH domain / Band 7 family
- protein heterodimerization
Pathways
Biological processes and signaling networks where the PHB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- impaired glucose tolerance
- demyelination
- epithelial cancer
- liver cancer
- neoplasia
- tumorigenesis
- hepatocellular carcinoma
- organismal death
- psoriasis
role in cell
- expression in
- survival
- apoptosis
- cell death
- growth
- phosphorylation in
- invasion by
- proliferation
- morphology
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- myelin enriched fraction
- nuclear fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- noncaveolar lipid raft
- exocytic vesicle
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
- inner nuclear membrane
- nucleoplasm
- nucleoli
- nuclear scaffolds
- synapse
- early endosomes
- membrane rafts
- chromatin
- postsynaptic density
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- negative regulation of cell proliferation
- negative regulation of protein catabolic process
- B cell activation
- positive regulation of neuron apoptotic process
- positive regulation of G-protein coupled receptor protein signaling pathway
- negative regulation of androgen receptor signaling pathway
- positive regulation of smooth muscle cell proliferation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- cellular response to interleukin-6
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- positive regulation of interleukin-17 production
- positive regulation of immunoglobulin production
- osteoblast differentiation
- DNA biosynthetic process
- signal transduction
- positive regulation of complement activation
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- mitochondrion organization
- regulation of gene expression, epigenetic
- CD40 signaling pathway
- negative regulation of transcription by competitive promoter binding
- positive regulation of gene expression
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of ERK1 and ERK2 cascade
- progesterone receptor signaling pathway
- RIG-I signaling pathway
- protein stabilization
- T-helper 17 type immune response
- positive regulation of protein kinase B signaling cascade
- negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- membrane
- mitochondrial prohibitin complex
- plasma membrane
- mitochondrial inner membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- complement component C3a binding
- complement component C3b binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- protein heterodimerization activity
- proteinase activated receptor binding
- enzyme binding