DTYMK Gene Summary [Human]
Enables thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within cellular response to growth factor stimulus and nucleotide biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DTYMK |
| Official Name | deoxythymidylate kinase [Source:HGNC Symbol;Acc:HGNC:3061] |
| Ensembl ID | ENSG00000168393 |
| Bio databases IDs | |
| Aliases | deoxythymidylate kinase, dTMP kinase, thymidylate (dTMP) kinase |
| Synonyms | CDC8, CONPM, D10Ertd203e, deoxythymidylate kinase, LOC727761, mtmk, PP3731, Tmk, TMPK, TYMK, TYPK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTYMK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- dTMP kinase
- NK
- ATP binding
- Thymidylate kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- prostate cancer
- epithelial cancer
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- organismal death
- testicular germ cell tumor
role in cell
- production in
- expression in
- apoptosis
- phosphorylation in
- growth
- binding in
- migration
- proliferation
- survival
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTYMK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- cellular response to growth factor stimulus
- dTDP biosynthetic process
- thymidine biosynthetic process
- myoblast differentiation
- response to cadmium ion
- nucleoside monophosphate phosphorylation
- dUDP biosynthetic process
- dTTP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- thymidylate kinase activity
- ATP binding
- nucleoside diphosphate kinase activity