SLC16A4 Gene Summary [Human]
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC16A4 |
| Official Name | solute carrier family 16 member 4 [Source:HGNC Symbol;Acc:HGNC:10925] |
| Ensembl ID | ENSG00000168679 |
| Bio databases IDs | |
| Aliases | solute carrier family 16 member 4 |
| Synonyms | MCT4, MCT 5, SDC16A4, solute carrier family 16 member 4, solute carrier family 16, member 4, solute carrier family 16 (monocarboxylic acid transporters), member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC16A4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Major Facilitator Superfamily
- protein binding
- monocarboxylic acid transporter
- monocarboxylate transporter 1
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- streptozotocin-induced diabetic nephropathy
- idiopathic scoliosis
- hepatitis B virus-related hepatocellular carcinoma
- gastric carcinoma
- gastric epithelial cancer
regulates
- monocarboxylic acid
- 4-hydroxybutanoic acid
- lactic acid
- BSG
- L-lactic acid
role in cell
- quantity
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane vesicles
- cell surface
- perinuclear region
- cellular membrane
- membrane blebs
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC16A4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- monocarboxylic acid transport
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- symporter activity
- monocarboxylic acid transmembrane transporter activity