GLIPR2 Gene Summary [Human]
Enables protein homodimerization activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; and positive regulation of epithelial to mesenchymal transition. Located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GLIPR2 |
| Official Name | GLI pathogenesis related 2 [Source:HGNC Symbol;Acc:HGNC:18007] |
| Ensembl ID | ENSG00000122694 |
| Bio databases IDs | |
| Aliases | GLI pathogenesis related 2 |
| Synonyms | 5730414A08Rik, C9ORF19, GAPR-1, GLI pathogenesis-related 2, LOC684484 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLIPR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLIPR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epithelial to mesenchymal transition
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity