PLA2G4F Gene Summary [Human]
Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to act upstream of or within several processes, including arachidonic acid secretion; cellular response to antibiotic; and prostaglandin biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol; ruffle membrane; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLA2G4F |
| Official Name | phospholipase A2 group IVF [Source:HGNC Symbol;Acc:HGNC:27396] |
| Ensembl ID | ENSG00000168907 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IVF |
| Synonyms | 4732472I07, 4732472I07Rik, Cpla2zeta, Gm647, LOC688015, phospholipase A2 group IVF, phospholipase A2, group IVF, PLA2G4FZ, Pla2zeta |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA2G4F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Patatins and Phospholipases
- Cytoplasmic phospholipase A2, catalytic subunit
- lysophospholipase
- phospholipase A1
- Cytosolic phospholipases A2 C2-domain
- Lysophospholipase catalytic domain
- calcium-dependent phospholipase A2
- enzyme
- Protein kinase C conserved region 2 (CalB)
- phospholipase A2
- C2 domain
Pathways
Biological processes and signaling networks where the PLA2G4F gene in human plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Phagosome Formation
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- psoriasis
- diabetes mellitus
- lung adenocarcinoma formation
- Chagas cardiomyopathy
regulates
- 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine
- fatty acid
- arachidonic acid
- prostaglandin
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA2G4F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- arachidonic acid secretion
- glycerophospholipid catabolic process
- prostaglandin biosynthetic process
- cellular response to antibiotic
- phosphatidylglycerol acyl-chain remodeling
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- vesicle
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phosphatidylcholine 1-acylhydrolase activity
- calcium-dependent phospholipid binding