CSGALNACT2 Gene Summary [Human]
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | CSGALNACT2 |
| Official Name | chondroitin sulfate N-acetylgalactosaminyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:24292] |
| Ensembl ID | ENSG00000169826 |
| Bio databases IDs | |
| Aliases | chondroitin sulfate N-acetylgalactosaminyltransferase 2, chondroitin beta1,4 N-acetylgalactosaminyltransferase 2, glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase 2 |
| Synonyms | 4632415D10Rik, beta4GalNAcT, CHGN2, chondroitin sulfate N-acetylgalactosaminyltransferase 2, chondroitin sulphate N-acetylgalactosaminyltransferase 2, GALNACT-2, PRO0082, RGD1563660 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSGALNACT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylgalactosaminyltransferase
- Chondroitin N-acetylgalactosaminyltransferase
- glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
- enzyme
- protein binding
- glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- dyspnea
- cyanosis
- plasma cell myeloma
- respiratory failure
- inguinal hernia
regulates
- cyclic AMP
- chondroitin sulfate proteoglycan
- ADRB1
- proteoglycan
- chondroitin sulfate
- chondroitin
- chondroitin sulfate B proteoglycan
role in cell
- molecular cleavage in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSGALNACT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- chondroitin sulfate biosynthetic process
- chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- chondroitin sulfate proteoglycan biosynthetic process
- dermatan sulfate proteoglycan biosynthetic process
- proteoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
- glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
- acetylgalactosaminyltransferase activity