USP5 Gene Summary [Human]
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | USP5 |
| Official Name | ubiquitin specific peptidase 5 [Source:HGNC Symbol;Acc:HGNC:12628] |
| Ensembl ID | ENSG00000111667 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 5, isopeptidase T |
| Synonyms | AA407472, ISOT, ISOT-1, LOC100911959, Ubiquitin Carboxy Terminal Hydrolase 5, ubiquitin specific peptidase 5, ubiquitin specific peptidase 5 (isopeptidase T), Ubiquitin thioesterase 5, Ucht |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- cysteine endopeptidase
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- ubiquitin binding
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- Peptidase_C19
- Variant UBP zinc finger
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- lung cancer
- hepatocellular carcinoma
- liver cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- production in
- expression in
- activation in
- growth
- proliferation
- ferroptosis
- migration
- double-stranded DNA break repair in
- ubiquitination in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- cytosol
- synaptic vesicles
- synaptosomes
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- protein ubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- protein binding
- ubiquitin binding
- cysteine-type endopeptidase activity