SOCS5
SOCS5 Gene Summary
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SOCS5 |
| Official Name | suppressor of cytokine signaling 5 [Source:HGNC Symbol;Acc:HGNC:16852] |
| Ensembl ID | ENSG00000171150 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 5 |
| Synonyms | 1810018L08Rik,CIS5,CIS6,Cish5,CISH6,mKIAA0671,RGD1564914,suppressor of cytokine signaling 5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- receptor tyrosine kinase binding
- epidermal growth factor receptor binding
- Src homology 2 (SH2) domain
- SOCS
- protein binding
- cytokine
- Suppressor of cytokine signalling
Pathways
Biological processes and signaling networks where the SOCS5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ERBB2
- EGFR
- DDX39A
- ALK
- IL4R
- KIT
- GRB2
- miR-21-5p (and other miRNAs w/seed AGCUUAU)
- STAT1
- mir-8 (includes others)
disease
- Huntington disease
- thyroid cancer
- uveitis
regulated by
- EPO
- Immunoglobulin
- levodopa
- IL6
- TAF4
- metformin
- PHB2
- EGF
- ID3
- ID2
regulates
- HIF1A
- IL6
- STAT3
- JAK
- IL6R
- IL6ST
- IL4R
- IL13RA1
- LIFR
- IL2RG
role in cell
- expression in
- migration
- differentiation
- damage
- mitogenesis in
- invasion by
- damage in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SOCS5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of T-helper 2 cell differentiation
- positive regulation of T-helper 1 cell differentiation
- negative regulation of epidermal growth factor-activated receptor activity
- epidermal growth factor receptor signaling pathway
- negative regulation of inflammatory response
- phosphatidylinositol phosphorylation
- JAK-STAT cascade
- negative regulation of interleukin-6 production
- negative regulation of signal transduction
- cytokine-mediated signaling pathway
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of monocyte chemotactic protein-1 production
- cellular response to low-density lipoprotein particle stimulus
- intracellular signal transduction
- protein ubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- epidermal growth factor receptor binding
- 1-phosphatidylinositol-3-kinase regulator activity
- receptor tyrosine kinase binding