PBXIP1 Gene Summary [Human]
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | PBXIP1 |
| Official Name | PBX homeobox interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21199] |
| Ensembl ID | ENSG00000163346 |
| Bio databases IDs | |
| Aliases | PBX homeobox interacting protein 1 |
| Synonyms | 4732463H20Rik, HPIP, MGC38361, PBX homeobox interacting protein 1, pre B cell leukaemia transcription factor interacting protein 1, pre B cell leukemia transcription factor interacting protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PBXIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- transcription co-repressor
- transcription factor binding
- protein binding
- Cell division protein ZapB
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardioembolic stroke
- Parkinson disease
role in cell
- proliferation
- colony formation
- differentiation
- quantity
- adhesion
- accumulation
- disassembly
- ubiquitination in
- activation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PBXIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- production of molecular mediator involved in inflammatory response
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- hemopoiesis
- extracellular matrix disassembly
- regulation of Rho guanyl-nucleotide exchange factor activity
- cell adhesion
- positive regulation of Wnt receptor signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- membrane
- cytosol
- chromatin
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- transcription corepressor activity