ISYNA1 Gene Summary [Human]
This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ISYNA1 |
| Official Name | inositol-3-phosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:29821] |
| Ensembl ID | ENSG00000105655 |
| Bio databases IDs | |
| Aliases | inositol-3-phosphate synthase 1, myo-inositol 1-phosphate synthase |
| Synonyms | 1300017C10Rik, INO1, INOS, inositol-3-phosphate synthase 1, IPS, IPS-1, Isyna1 alpha, Isyna1 α, MIPS, myo-inositol 1-phosphate synthase A1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ISYNA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myo-inositol-1-phosphate synthase
- inositol-3-phosphate synthase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- organismal death
- ovarian cancer
- early onset hypertension
role in cell
- expression in
- quantity
- proliferation
- migration
- invasion by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ISYNA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol biosynthetic process
- phospholipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- inositol-3-phosphate synthase activity
- protein binding