DEFB103A Gene Summary [Human]
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | DEFB103A |
| Official Name | defensin beta 103A [Source:HGNC Symbol;Acc:HGNC:15967] |
| Ensembl ID | ENSG00000176797 |
| Bio databases IDs | |
| Aliases | defensin beta 103A, beta defensin 3, beta defensin-3, beta-defensin 3 |
| Synonyms | AC246795.6, BD-3, DEFB103, DEFB-3, defensin beta 103A, defensin β 103A, HBD3, HBP-3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DEFB103A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- protein binding
Pathways
Biological processes and signaling networks where the DEFB103A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DEFB103A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- killing by host of symbiont cells
- defense response to Gram-negative bacterium
- positive chemotaxis
- killing of cells of other organism
- defense response to bacterium
- defense response to Gram-positive bacterium
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemoattractant activity
- CCR6 chemokine receptor binding