TIMM22 Gene Summary [Human]
Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | TIMM22 |
| Official Name | translocase of inner mitochondrial membrane 22 [Source:HGNC Symbol;Acc:HGNC:17317] |
| Ensembl ID | ENSG00000177370 |
| Bio databases IDs | |
| Aliases | translocase of inner mitochondrial membrane 22 |
| Synonyms | COXPD43, TEX4, TIM22, translocase of inner mitochondrial membrane 22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIMM22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- protein binding
- Tim17/Tim22/Tim23/Pmp24 family
- transporter
Pathways
Biological processes and signaling networks where the TIMM22 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIMM22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- protein import into mitochondrial inner membrane
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane protein insertion complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- mitochondrion targeting sequence binding
- protein binding
- protein transmembrane transporter activity