ARAP1 Gene Summary [Human]
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ARAP1 |
| Official Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [Source:HGNC Symbol;Acc:HGNC:16925] |
| Ensembl ID | ENSG00000186635 |
| Bio databases IDs | |
| Aliases | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
| Synonyms | 2410002L19Rik, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, CENTD2, cnt-d2, KIAA0782, mKIAA0782 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- SMAD binding
- nucleic acid binding
- SAM (Sterile alpha motif )
- G-protein-coupled receptor binding
- transcription factor binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RhoGAP
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- GTPase-activator protein for Rho-like GTPases
- sequence-specific DNA binding
- Arf-GAP domain
- Sterile alpha motif
- phosphatidylinositol-3,4,5-triphosphate binding
- double-stranded DNA binding
- Putative GTP-ase activating proteins for the small GTPase, ARF
- Ubl1_cv_Nsp3_N-like
- SAM domain (Sterile alpha motif)
- PH domain
- transcription factor activity
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- rheumatoid arthritis
- insomnia
- gestational diabetes mellitus
- periodontitis
- alloimmune disorder
role in cell
- cell rounding
- formation
- phagocytosis by
- quantity
- maintenance
- organization
- morphology
- assembly
- 5-fluorouracil resistance
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear Golgi regions
- podosomes
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi stacks
- trans Golgi network
- nucleoplasm
- early endosomes
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of stress fiber assembly
- positive regulation of receptor recycling
- signal transduction
- regulation of small GTPase mediated signal transduction
- positive regulation of filopodium assembly
- actin filament organization
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
- Golgi cisterna membrane
- intracellular membrane-bounded organelle
- cytosol
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- type 1 angiotensin receptor binding
- metal ion binding
- GTPase activator activity