PTPN9 Gene Summary [Human]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PTPN9 |
| Official Name | protein tyrosine phosphatase non-receptor type 9 [Source:HGNC Symbol;Acc:HGNC:9661] |
| Ensembl ID | ENSG00000169410 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase non-receptor type 9 |
| Synonyms | MEG2, protein tyrosine phosphatase non-receptor type 9, protein tyrosine phosphatase, non-receptor type 9, PTPMEG2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPN9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- non-membrane spanning protein tyrosine phosphatase
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- protein binding
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- CRAL/TRIO, N-terminal domain
- Divergent CRAL/TRIO domain
- phosphatase
- CRAL/TRIO domain
- Sec14 domain
Pathways
Biological processes and signaling networks where the PTPN9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- growth failure
- breast carcinoma
- pancreatic epithelial cancer
- tremor
- meningomyelocele
- bleeding
- exencephaly
- encephalocele
- diabetes mellitus
role in cell
- expression in
- growth
- activation in
- proliferation
- survival
- differentiation
- degranulation
- diameter
- aggregation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- granules
- nucleoplasm
- nerve ending
- secretory vesicles
- specific granules
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPN9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- protein dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- neuron projection terminus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity