DTX3 Gene Summary [Human]
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | DTX3 |
| Official Name | deltex E3 ubiquitin ligase 3 [Source:HGNC Symbol;Acc:HGNC:24457] |
| Ensembl ID | ENSG00000178498 |
| Bio databases IDs | |
| Aliases | deltex E3 ubiquitin ligase 3 |
| Synonyms | Deltex3, deltex 3, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3, FLJ34766, mg310, RGD1566181, RNF154 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- Ring finger domain
- protein binding
- Domain found at the C-terminus of deltex-like
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the DTX3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transferase activity