UBE2E2 Gene Summary [Human]
Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBE2E2 |
| Official Name | ubiquitin conjugating enzyme E2 E2 [Source:HGNC Symbol;Acc:HGNC:12478] |
| Ensembl ID | ENSG00000182247 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 E2 |
| Synonyms | BC016265, FLJ25157, LOC683661, UBCH8, ubiquitin-conjugating enzyme E2E 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2E2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- ISG15 conjugating enzyme
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2E2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- ovarian cancer
- diabetes mellitus
- organismal death
- diabetic retinopathy
- asthma
- Wegener granulomatosis
- eczema
- vitiligo
role in cell
- expression in
- synthesis in
- activation in
- migration
- DNA damage response
- conjugation in
- replication in
- ubiquitination in
- isgylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2E2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- positive regulation of G1/S transition of mitotic cell cycle
- ISG15-protein conjugation
- protein K63-linked ubiquitination
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- protein binding
- ISG15 ligase activity