ZFP42 Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZFP42 |
| Official Name | ZFP42 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:30949] |
| Ensembl ID | ENSG00000179059 |
| Bio databases IDs | |
| Aliases | ZFP42 zinc finger protein |
| Synonyms | LOC100364508, REX-1, ZFP42 zinc finger protein, Zfp971, zinc finger protein 42, ZNF754 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFP42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the ZFP42 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- testicular germ cell tumor
- germ cell neoplasia
- yolk sac neoplasm
- oligozoospermia
role in cell
- expression in
- number
- proliferation
- differentiation
- adipogenic potential
- abnormal morphology
- inactivation
- pluripotency
- osteogenic differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFP42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- male gonad development
- female gonad development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cytoplasm
- PcG protein complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity