ZNRF2 Gene Summary [Human]
Enables ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNRF2 |
| Official Name | zinc and ring finger 2 [Source:HGNC Symbol;Acc:HGNC:22316] |
| Ensembl ID | ENSG00000180233 |
| Bio databases IDs | |
| Aliases | zinc and ring finger 2 |
| Synonyms | 1190002C14Rik, D6Ertd365e, Nin283, RNF202, zinc and ring finger 2, Znrf1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNRF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- zinc finger domain
- RING-like zinc finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNRF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cell projection
- fibrillar center
- plasma membrane
- lysosomal membrane
- nucleoplasm
- cytoplasmic vesicle membrane
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- macromolecular complex
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding