PPP6C Gene Summary [Human]
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPP6C |
| Official Name | protein phosphatase 6 catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9323] |
| Ensembl ID | ENSG00000119414 |
| Bio databases IDs | |
| Aliases | protein phosphatase 6 catalytic subunit |
| Synonyms | 2310003C10Rik, LOC171121, PP6, PP6C, PPP6, protein phosphatase 6 catalytic subunit, protein phosphatase 6, catalytic subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP6C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine phosphatase
- phosphatase
- metallophosphatase superfamily, metallophosphatase domain
- Protein phosphatase 2A homologues, catalytic domain
- protein binding
- Calcineurin-like phosphoesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- skin basal cell carcinoma
- basal cell skin cancer
- chronic lymphocytic leukemia
- papillomatosis
- benign neoplasia
- cannabis dependence
- opioid-related disorder
role in cell
- phosphorylation in
- survival
- polyubiquitination in
- signaling in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP6C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- protein dephosphorylation
- G1/S transition of mitotic cell cycle
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity