ZDHHC20 Gene Summary [Human]
Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in intracellular membrane-bounded organelle and plasma membrane. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ZDHHC20 |
| Official Name | zinc finger DHHC-type palmitoyltransferase 20 [Source:HGNC Symbol;Acc:HGNC:20749] |
| Ensembl ID | ENSG00000180776 |
| Bio databases IDs | |
| Aliases | zinc finger DHHC-type palmitoyltransferase 20 |
| Synonyms | 4930542A17Rik, 4933421L13Rik, 5033406L14RIK, AI448102, B230110O18Rik, DHHC-20, FLJ25952, HK11, RGD1305755, zD20, zinc finger, DHHC domain containing 20, zinc finger DHHC-type palmitoyltransferase 20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZDHHC20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- zinc ion binding
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- schizophrenia
- lung adenocarcinoma
- lung adenocarcinoma formation
- infection by Influenza A virus subtype H1N1
- productive infection by HIV-1
role in cell
- invasion by
- palmitoylation in
- S-palmitoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZDHHC20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-L-cysteine S-palmitoylation
- protein palmitoylation
- synaptic vesicle maturation
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- intracellular membrane-bounded organelle
- membrane
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- zinc ion binding
- protein-cysteine S-myristoyltransferase activity
- palmitoyltransferase activity