RNF41 Gene Summary [Human]
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | RNF41 |
| Official Name | ring finger protein 41 [Source:HGNC Symbol;Acc:HGNC:18401] |
| Ensembl ID | ENSG00000181852 |
| Bio databases IDs | |
| Aliases | ring finger protein 41 |
| Synonyms | 2210404G21RIK, 4930511A05Rik, 4933415P08Rik, D10Ertd722e, FLRF, LOC100506719, NRDP1, ring finger protein 41, SBBI03 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF41 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- interleukin-3 receptor binding
- enzyme binding
- coiled-coil domain
- protein domain specific binding
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- USP8 interacting
- receptor tyrosine kinase binding
- RING-type zinc-finger
- erythropoietin receptor binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- ubiquitin-protein transferase activity
- zinc finger domain
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the RNF41 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- advanced cancer
- insulin resistance
- endotoxin shock response
- chronic lymphocytic leukemia
- androgenic alopecia
- infection by vesicular stomatitis virus
role in cell
- activation in
- expression in
- phosphorylation in
- proliferation
- differentiation
- accumulation in
- migration
- migration by
- production in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum tubules
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF41 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lymphocyte differentiation
- regulation of MAPK cascade
- protein polyubiquitination
- negative regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- positive regulation of protein catabolic process
- regulation of myeloid cell differentiation
- regulation of protein kinase B signaling cascade
- autophagy
- regulation of reactive oxygen species metabolic process
- negative regulation of cell migration
- positive regulation of reactive oxygen species metabolic process
- protein autoubiquitination
- proteasomal protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- endoplasmic reticulum tubular network
- cytosol
Molecular Function
What the gene product does at the molecular level
- erythropoietin receptor binding
- ubiquitin-protein ligase activity
- identical protein binding
- protein domain specific binding
- zinc ion binding
- protein binding
- small GTPase binding
- interleukin-3 receptor binding
- receptor tyrosine kinase binding