TGS1
TGS1 Gene Summary
Enables RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TGS1 |
| Official Name | trimethylguanosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:17843] |
| Ensembl ID | ENSG00000137574 |
| Bio databases IDs | |
| Aliases | trimethylguanosine synthase 1 |
| Synonyms | D4Ertd800e,KW2,NCOA6IP,PIMT,PIPMT,trimethylguanosine synthase 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
Pathways
Biological processes and signaling networks where the TGS1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EEF1A2
- FBL
- NOXA1
- LURAP1
- NCOA6
- MYH7
- SNRPF
- NOP58
- SNRNP70
- CFTR
disease
- non-insulin-dependent diabetes mellitus
- impaired glucose tolerance
- hyperglycemia
- hypoinsulinemia
regulated by
- lipopolysaccharide
- insulin
- PTPN1
- CITED2
- CHKB
- IL13
regulates
- CCND1
- DDIT3
- HSPA5
- HERPUD1
- insulin
- CCND2
- Rxra
- ANKS4B
- D-glucose
- TMX4
role in cell
- expression in
- apoptosis
- processing in
- capping in
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TGS1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- ribonucleoprotein complex biogenesis
- spliceosomal snRNP assembly
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- Cajal body
- cytosol
- nucleolus
- small nuclear ribonucleoprotein complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- RNA methyltransferase activity
- RNA trimethylguanosine synthase activity
- protein binding