PRMT3 Gene Summary [Human]
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | PRMT3 |
| Official Name | protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163] |
| Ensembl ID | ENSG00000185238 |
| Bio databases IDs | |
| Aliases | protein arginine methyltransferase 3 |
| Synonyms | 2010005E20Rik, 2410018A17Rik, HRMT1L3, protein arginine methyltransferase 3, protein arginine N-methyltransferase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRMT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- histone methyltransferase
- binding protein
- catalytic domain
- enzyme
- protein binding
- zinc finger domain
- AdoMet_MTases
- protein-arginine N-methyltransferase
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
Pathways
Biological processes and signaling networks where the PRMT3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma formation
- rheumatoid arthritis
- lung adenocarcinoma
- tumorigenesis
- pancreatic carcinoma
- pancreatic epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- differentiation
- replication in
- oxaliplatin resistance
- morphogenesis
- dimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRMT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of retinoic acid biosynthetic process
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- negative regulation of protein ubiquitination
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- protein binding
- metal ion binding
- ribosome binding
- histone methyltransferase activity
- protein-arginine omega-N monomethyltransferase activity
- protein-arginine N-methyltransferase activity
- methyltransferase activity