NOTUM Gene Summary [Human]
Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NOTUM |
| Official Name | notum, palmitoleoyl-protein carboxylesterase [Source:HGNC Symbol;Acc:HGNC:27106] |
| Ensembl ID | ENSG00000185269 |
| Bio databases IDs | |
| Aliases | notum, palmitoleoyl-protein carboxylesterase, [Wnt protein] O-palmitoleoyl-L-serine hydrolase |
| Synonyms | 5730593N15Rik, hNOTUM, notum palmitoleoyl-protein carboxylesterase, NOTUM, palmitoleoyl-protein carboxylesterase, RGD1307119 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOTUM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- Pectinacetylesterase
- lipase
- enzyme
- protein binding
- phospholipase C
Pathways
Biological processes and signaling networks where the NOTUM gene in human plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Gustation Pathway
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOTUM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- regulation of bone mineralization
- bone development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- phospholipase C activity