RASA3 Gene Summary [Human]
This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | RASA3 |
| Official Name | RAS p21 protein activator 3 [Source:HGNC Symbol;Acc:HGNC:20331] |
| Ensembl ID | ENSG00000185989 |
| Bio databases IDs | |
| Aliases | RAS p21 protein activator 3 |
| Synonyms | E130011G04, GAP1IP4BP, Gap3, GAPIII, hlb381, RASGAP3, RAS p21 protein activator 3, R-RAS GAP, scat |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- BTK motif
- GTPase-activator protein for Ras-like GTPase
- PH domain
- GTPase activator
- Pleckstrin homology-like domain
- Protein kinase C conserved region 2 (CalB)
- ion channel
- calcium-release channel
- calcium channel regulator
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- bleeding
- hepatocellular carcinoma
- epithelial cancer
- edema
- experimental autoimmune encephalomyelitis
- major depression
- silicosis
- androgenic alopecia
role in cell
- development
- generation
- response by
- differentiation
- binding in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- signal transduction
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-release channel activity
- metal ion binding
- GTPase activator activity