SPRY4 Gene Summary [Human]
This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | SPRY4 |
| Official Name | sprouty RTK signaling antagonist 4 [Source:HGNC Symbol;Acc:HGNC:15533] |
| Ensembl ID | ENSG00000187678 |
| Bio databases IDs | |
| Aliases | sprouty RTK signaling antagonist 4 |
| Synonyms | A030006O18Rik, HH17, SMAG84, sprouty4, sprouty RTK signaling antagonist 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPRY4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase inhibitor activity
- protein binding
- zDHHC ankyrin repeat binding domain
- Raf binding domain
- cysteine rich domain
- Sprouty protein (Spry)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- benign neoplasia
- acute myeloid leukemia
- insomnia
- hypogonadotropic hypogonadism 17 without anosmia
- hypogonadotropic hypogonadism 17
- malocclusion
- anaplastic thyroid cancer
- cyclopia
- Kallmann syndrome type 17
role in cell
- migration
- expression in
- activation in
- growth
- apoptosis
- signaling in
- proliferation
- differentiation
- function
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell periphery
- perinuclear region
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPRY4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of MAP kinase activity
- negative regulation of Ras protein signal transduction
- negative regulation of substrate adhesion-dependent cell spreading
- organ development
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- cytosol
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase inhibitor activity