Spry4 Gene Summary [Mouse]
Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of MAP kinase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; germ layer; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spry4 |
| Official Name | sprouty RTK signaling antagonist 4 [Source:MGI Symbol;Acc:MGI:1345144] |
| Ensembl ID | ENSMUSG00000024427 |
| Bio databases IDs | |
| Aliases | sprouty RTK signaling antagonist 4 |
| Synonyms | A030006O18Rik, HH17, SMAG84, sprouty4, sprouty RTK signaling antagonist 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spry4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase inhibitor activity
- protein binding
- zDHHC ankyrin repeat binding domain
- Raf binding domain
- cysteine rich domain
- Sprouty protein (Spry)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- benign neoplasia
- acute myeloid leukemia
- insomnia
- hypogonadotropic hypogonadism 17 without anosmia
- hypogonadotropic hypogonadism 17
- malocclusion
- anaplastic thyroid cancer
- cyclopia
- Kallmann syndrome type 17
role in cell
- migration
- expression in
- activation in
- growth
- apoptosis
- signaling in
- proliferation
- differentiation
- function
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell periphery
- perinuclear region
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spry4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of MAP kinase activity
- negative regulation of Ras protein signal transduction
- negative regulation of substrate adhesion-dependent cell spreading
- organ development
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- cytosol
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase inhibitor activity