YAF2 Gene Summary [Human]
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | YAF2 |
| Official Name | YY1 associated factor 2 [Source:HGNC Symbol;Acc:HGNC:17363] |
| Ensembl ID | ENSG00000015153 |
| Bio databases IDs | |
| Aliases | YY1 associated factor 2 |
| Synonyms | 2810021M11Rik, LOC681599, YY1 associated factor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YAF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Yaf2/RYBP C-terminal binding motif
- transcription co-activator
- Zn-finger in Ran binding protein and others
- transcription co-repressor
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
role in cell
- proliferation
- expression in
- compaction
- transformation
- mono-ubiquitination in
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YAF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- transcription corepressor activity
- metal ion binding