Greb1 Gene Summary [Mouse]
Predicted to be involved in morphogenesis of an epithelium. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; incisor; retina nuclear layer; and tail unsegmented mesenchyme. Orthologous to human GREB1 (growth regulating estrogen receptor binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Greb1 |
| Official Name | gene regulated by estrogen in breast cancer protein [Source:MGI Symbol;Acc:MGI:2149712] |
| Ensembl ID | ENSMUSG00000036523 |
| Bio databases IDs | |
| Aliases | gene regulated by estrogen in breast cancer protein |
| Synonyms | 5730583K22Rik, 9130004E13, Gene regulated by estrogen in breast cancer, gene regulated by estrogen in breast cancer protein, growth regulating estrogen receptor binding 1, KIAA0575, mKIAA0575, RGD1564091 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Greb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GREB1 N-terminal region
- GREB1 C-terminal region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometriosis
- breast carcinoma
- metastasis
- organismal death
- asthma
- neuroblastoma
- neuroblastoma formation
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- proliferation
- migration
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Greb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- nucleoplasm