IGFBP4 Gene Summary [Human]
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IGFBP4 |
| Official Name | insulin like growth factor binding protein 4 [Source:HGNC Symbol;Acc:HGNC:5473] |
| Ensembl ID | ENSG00000141753 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 4, IGF-binding protein 4 |
| Synonyms | BP-4, DEB2, HT29-IGFBP, IBP-4, IGF-BP, insulin-like growth factor binding protein 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGFBP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TY
- insulin-like growth factor binding
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
- cleavage site
Pathways
Biological processes and signaling networks where the IGFBP4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- hepatocellular carcinoma
- organismal death
- epithelial cancer
- liver cancer
- dermatomyositis
- survival
- streptozotocin-induced diabetic nephropathy
- serous ovarian cancer
role in cell
- apoptosis
- expression in
- proliferation
- growth
- migration
- colony formation
- adipogenesis in
- steroidogenesis in
- abnormal morphology
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGFBP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- MAPK cascade
- regulation of glucose metabolic process
- signal transduction
- regulation of cell growth
- type B pancreatic cell proliferation
- positive regulation of MAPK cascade
- response to organic cyclic compound
- regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of insulin-like growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding