CSF2RA Gene Summary [Human]
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CSF2RA |
| Official Name | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] |
| Ensembl ID | ENSG00000198223 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 2 receptor subunit alpha, alpha-GM-CSF receptor |
| Synonyms | alphaGMR, CD116, CDw116, colony stimulating factor 2 receptor subunit alpha, colony stimulating factor 2 receptor subunit α, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSFR, GM-CSF-R-alpha, GM-CSF receptor, GM-CSF receptor alpha CHAIN, Gmcsf receptor α, GM-CSF receptor α CHAIN, GM-CSF-R-α, GMR, GMR-alpha, GMR-α, MGMR alpha, MGMR α, SGMR alpha, SGMR α, SMDP4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSF2RA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- IL-3 receptor alpha chain N-terminal domain
- signaling receptor activity
- cytoplasmic domain
- FN3
- transmembrane domain
- extracellular ligand binding domain
- intracellular domain
- protein binding
- membrane-proximal domain
- transmembrane receptor
- Sh3 domain binding motif
Pathways
Biological processes and signaling networks where the CSF2RA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck cancer
- Alzheimer disease
- atopic dermatitis
- infection
- stage 4s neuroblastoma
- pulmonary surfactant metabolism dysfunction type 4
- lymphoma
- HIV infection
- nosocomial infection
role in cell
- binding
- apoptosis
- growth
- phosphorylation in
- migration
- proliferation
- differentiation
- survival
- colony formation
- shape change
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSF2RA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- granulocyte-macrophage colony-stimulating factor signaling pathway
- cytokine-mediated signaling pathway
- positive regulation of leukocyte proliferation
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- granulocyte macrophage colony-stimulating factor receptor complex
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- cytokine binding
- cytokine receptor activity