CISH Gene Summary [Human]
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Details
| Type | Retained Intron |
| Official Symbol | CISH |
| Official Name | cytokine inducible SH2 containing protein [Source:HGNC Symbol;Acc:HGNC:1984] |
| Ensembl ID | ENSG00000114737 |
| Bio databases IDs | |
| Aliases | cytokine inducible SH2 containing protein |
| Synonyms | BACTS2, CIS, CIS-1, cytokine inducible SH2-containing protein, F17, F23, G18, SOCS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CISH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- elongin B/C binding domain
- SOCS
- Src homology 2 (SH2) domain
- protein binding
- Cullin-box
Pathways
Biological processes and signaling networks where the CISH gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- susceptibility to malaria
- lung cancer
- pulmonary fibrosis
- serum transfer induced arthritis
- hyperplasia
- insulin-dependent diabetes mellitus
- hypersensitivity reaction type I
- susceptibility to bacteremia type 2
- high-fat diet-induced obesity
role in cell
- production in
- proliferation
- expression in
- activation in
- phosphorylation in
- degradation in
- quantity
- activation
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CISH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- regulation of cell growth
- phosphatidylinositol phosphorylation
- protein kinase C-activating G-protein coupled receptor signaling pathway
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- 1-phosphatidylinositol-3-kinase regulator activity