FICD Gene Summary [Human]
Enables several functions, including ATP binding activity; Hsp70 protein binding activity; and chaperone binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FICD |
| Official Name | FIC domain protein adenylyltransferase [Source:HGNC Symbol;Acc:HGNC:18416] |
| Ensembl ID | ENSG00000198855 |
| Bio databases IDs | |
| Aliases | FIC domain protein adenylyltransferase, huntingtin interacting protein 13, fic S-phase protein cell division homolog (E. coli) |
| Synonyms | D5Ertd40e, FIC domain containing, FIC domain protein adenylyltransferase, HIP13, HYPE, SPG92, UNQ3041 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FICD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- nucleotidyltransferase
- ATP binding
- protein homodimerization
- enzyme
- protein binding
- chaperone binding
- tetratricopeptide repeat
- identical protein binding
- phosphoric diester hydrolase
- Fic/DOC family
Pathways
Biological processes and signaling networks where the FICD gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear lamina
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FICD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of GTPase activity
- response to unfolded protein
- response to endoplasmic reticulum stress
- protein deadenylylation
- protein adenylylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- chaperone binding
- protein adenylylhydrolase activity
- protein adenylyltransferase activity
- Hsp70 protein binding