DCAF12 Gene Summary [Human]
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
Details
| Type | Protein Coding |
| Official Symbol | DCAF12 |
| Official Name | DDB1 and CUL4 associated factor 12 [Source:HGNC Symbol;Acc:HGNC:19911] |
| Ensembl ID | ENSG00000198876 |
| Bio databases IDs | |
| Aliases | DDB1 and CUL4 associated factor 12, cancer/testis antigen 102 |
| Synonyms | 1500001L20Rik, 5830424K06Rik, CT102, DDB1 and CUL4 associated factor 12, KIAA1892, LOC100910422, TCC52, WDR40A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCAF12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- protein binding activity, bridging
- WD domain, G-beta repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCAF12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of autophagy
- T cell activation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- CUL4 RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding