MAGEA3 Gene Summary [Human]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAGEA3 |
| Official Name | MAGE family member A3 [Source:HGNC Symbol;Acc:HGNC:6801] |
| Ensembl ID | ENSG00000221867 |
| Bio databases IDs | |
| Aliases | MAGE family member A3, melanoma-associated antigen 3, antigen MZ2-D, MAGE-3 antigen, cancer/testis antigen family 1, member 3 |
| Synonyms | CT1.3, HIP8, HYPD, MAGE3, MAGEA3/6, MAGEA6, MAGE family member A3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAGEA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanoma associated antigen family N terminal
- MAGE homology domain
- protease binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- yolk sac neoplasm
- germ cell neoplasia
- esophageal adenocarcinoma
- esophageal carcinoma formation
- melanoma
- melanoma cancer
- rhabdomyosarcoma
- soft tissue sarcoma cancer
role in cell
- apoptosis
- activation
- autophagy by
- autophagy in
- induction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAGEA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of protein processing
- negative regulation of autophagy
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding