PPP1CB Gene Summary [Human]

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
PPP1CB
Official Name
protein phosphatase 1 catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9282]
Ensembl ID
ENSG00000213639
Bio databases IDs NCBI: 5500 Ensembl: ENSG00000213639
Aliases protein phosphatase 1 catalytic subunit beta, myosin phosphatase
Synonyms 1200010B19, CS1 beta, CS1 β, Dis2m2, HEL-S-80p, MP, NSLH2, PP-1B, PP1beta, PP1c, PP1-C beta II, PP1-C β II, PP-1D, Pp1 delta, Pp1 β, Pp1 δ, PPP1beta, PPP1CD, PPP1C delta, PPP1C δ, protein phosphatase 1 catalytic subunit beta, protein PHOSPHATASE 1 CATALYTIC subunit, beta isoform, protein phosphatase 1 catalytic subunit β, protein PHOSPHATASE 1 CATALYTIC subunit, β isoform
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1CB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Serine-threonine protein phosphatase N-terminal domain
  • protein kinase binding
  • myosin phosphatase
  • catalytic domain
  • phosphoprotein phosphatase
  • protein serine/threonine phosphatase
  • metallophosphatase superfamily, metallophosphatase domain
  • protein binding
  • MLCP
  • Calcineurin-like phosphoesterase
  • protein phosphatase
  • phosphatase
  • Protein phosphatase 2A homologues, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • Huntington disease
  • hereditary disorder
  • Noonan spectrum disorder
  • interstitial fibrosis
  • Noonan syndrome-like disorder with loose anagen hair 2
  • Noonan syndrome
  • peripheral arterial disease
  • oral squamous cell carcinoma
  • squamous cell cancer of the oral cavity
regulated by
  • FSH
  • dexamethasone
  • Jurkat E6.1 cells
  • beta-estradiol
  • lipopolysaccharide
  • FSHR
  • budesonide
  • BB0603
  • regulatory T lymphocytes
  • microcystin-LR
role in cell
  • activation in
  • expression in
  • cell viability
  • binding in
  • survival
  • phosphorylation in
  • growth
  • adhesion
  • threonine phosphorylation in
  • dephosphorylation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • postsynaptic density (PSD) fractions
  • Nucleus
  • cytosol
  • nucleoplasm
  • nucleoli
  • synaptosomes
  • telomeres

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PPP1CB gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • MAPK cascade
  • circadian regulation of gene expression
  • glycogen metabolic process
  • protein dephosphorylation
  • entrainment of circadian clock by photoperiod
  • regulation of cell adhesion
  • regulation of circadian rhythm

Cellular Component

Where in the cell the gene product is active
  • chromosome, telomeric region
  • nucleus
  • extracellular vesicular exosome
  • focal adhesion
  • cytoplasm
  • cytosol
  • PTW/PP1 phosphatase complex
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein serine/threonine phosphatase activity
  • protein kinase binding
  • protein binding
  • metal ion binding
  • phosphatase activity
  • myosin-light-chain-phosphatase activity
  • myosin phosphatase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.