MIR26A1 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR26A1 |
| Official Name | microRNA 26a-1 [Source:HGNC Symbol;Acc:HGNC:31610] |
| Ensembl ID | ENSG00000199075 |
| Bio databases IDs | |
| Aliases | microRNA 26a-1 |
| Synonyms | HSA-MIR-26A, hsa-miR-26a-1, hsa-mir-26a-2, hsa-miR-26b, MI0000574, microRNA 26a, microRNA 26a-1, microRNA 26a-2, microRNA 26b, MIR26A, MIR26A1, MIR26A2, MIR26B, MIRN26A, MIRN26A1, MIRN26A2, MIRN26B, mmu-miR-26, mmu-miR-26a, mmu-mir-26a-1, mmu-mir-26a-2, mmu-miR-26b, pri-miR-26a, rno-miR-26a, rno-miR-26b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR26A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR26A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- melanoma cancer
- melanoma
- benign neoplasia
- gastric cancer
- breast cancer
- cervical squamous cell carcinoma
role in cell
- apoptosis
- expression in
- proliferation
- cell viability
- cell cycle progression
- replication in
- migration
- growth
- invasion by
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR26A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system myelin maintenance
- negative regulation of MAPK cascade
- regulation of atrial cardiomyocyte membrane depolarization
- gene silencing by miRNA
- negative regulation of cell proliferation
- vascular endothelial growth factor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- transforming growth factor beta receptor signaling pathway
- negative regulation of cytokine production involved in inflammatory response
- negative regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of cholesterol efflux
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of BMP signaling pathway
- negative regulation of interleukin-6 production
- negative regulation of nitric-oxide synthase activity
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of heart rate
- negative regulation of interleukin-17 production
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding