MIR96 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR96 |
| Official Name | microRNA 96 [Source:HGNC Symbol;Acc:HGNC:31648] |
| Ensembl ID | ENSG00000199158 |
| Bio databases IDs | |
| Aliases | microRNA 96 |
| Synonyms | DFNA50, hsa-miR-96, microRNA 96, MIRN96, miRNA96, mmu-miR-96, rno-miR-96 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR96 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- epithelial cancer
- breast cancer
- prostate cancer
- hepatocellular carcinoma
- liver cancer
- multiple sclerosis
- pancreatic cancer
- metastatic melanoma
role in cell
- growth
- expression in
- proliferation
- apoptosis
- invasion by
- phosphorylation in
- function
- migration
- cell viability
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR96 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- cellular response to cholesterol
- negative regulation of high-density lipoprotein particle clearance
- positive regulation of cholesterol biosynthetic process
- mRNA cleavage involved in gene silencing by miRNA
- positive regulation of SREBP-mediated signaling pathway
- positive regulation of fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding