ARHGAP5 Gene Summary [Human]
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARHGAP5 |
| Official Name | Rho GTPase activating protein 5 [Source:HGNC Symbol;Acc:HGNC:675] |
| Ensembl ID | ENSG00000100852 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 5 |
| Synonyms | AU014947, GFI2, LRRGT00098, p190-B, p190BRhoGAP, p190Rhogap, p190RhoGAP-A, p190RhoGAP-B, RhoGAP5, Rho GTPase Activating Protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- p120rasgap binding domain
- Contains two conserved F residues
- SH2-domain binding
- Ras family
- GTPase
- GTPase activator
- enzyme
- protein binding
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- FF domain
- Rab subfamily of small GTPases
- pseudoGTPase domain found in the family of p190RhoGAP
- P-loop containing Nucleoside Triphosphate Hydrolases
- p190-A and -B Rho GAPs FF domain
Pathways
Biological processes and signaling networks where the ARHGAP5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- uterine neoplasm
- neoplasia
- COVID-19
- tumorigenesis
- Martsolf syndrome
- Hutchinson-Gilford progeria syndrome
- Vogt-Koyanagi-Harada disease
role in cell
- phosphorylation in
- expression in
- proliferation
- activation
- contractility
- adhesion
- size
- neuritogenesis
- migration by
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- Endoplasmic Reticulum
- actin filaments
- cytosol
- dendritic spines
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mammary gland development
- regulation of small GTPase mediated signal transduction
- regulation of cell size
- positive regulation of mesenchymal cell proliferation
- cell adhesion
- positive regulation of epithelial cell migration
- Rho protein signal transduction
- epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity
- SH2 domain binding