ARL4D Gene Summary [Human]
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021]
Details
| Type | Protein Coding |
| Official Symbol | ARL4D |
| Official Name | ADP ribosylation factor like GTPase 4D [Source:HGNC Symbol;Acc:HGNC:656] |
| Ensembl ID | ENSG00000175906 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 4D |
| Synonyms | 1110036H21RIK, ADP-ribosylation factor-like 4D, ARF4L, Arf4l predicted, Arfl4, ARF like GTPase 4D, Arl5, ARL6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL4D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- Signal recognition particle receptor beta subunit
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- osteoarthropathy
- group 3 medulloblastoma
- brain cancer
role in cell
- expression in
- growth
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL4D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- intracellular protein transport
- protein secretion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity