OLIG1 Gene Summary [Human]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | OLIG1 |
| Official Name | oligodendrocyte transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16983] |
| Ensembl ID | ENSG00000184221 |
| Bio databases IDs | |
| Aliases | oligodendrocyte transcription factor 1, oligodendrocyte-specific bHLH transcription factor 1, oligodendrocyte lineage transcription factor 1, basic domain, helix-loop-helix protein, class B, 6 |
| Synonyms | BHLHB6, BHLHE21, Olg-1, Oligo1, oligodendrocyte transcription factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OLIG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- medulloblastoma
- brain cancer
- hypomyelination
role in cell
- differentiation
- development
- quantity
- generation
- production
- abnormal morphology
- commitment
- binding in
- maturation
- patterning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OLIG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- neuron fate commitment
- positive regulation of transcription from RNA polymerase II promoter
- sensory organ development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding