Olig2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and positive regulation of oligodendrocyte differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; epidermis; future brain; genitourinary system; and sensory organ. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Olig2 |
| Official Name | oligodendrocyte transcription factor 2 [Source:MGI Symbol;Acc:MGI:1355331] |
| Ensembl ID | ENSMUSG00000039830 |
| Bio databases IDs | |
| Aliases | oligodendrocyte transcription factor 2 |
| Synonyms | BHLHB1, bHLHe19, Olg-2, OLIGO2, oligodendrocyte transcription factor 2, PRKCBP2, RACK17, RK17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Olig2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription repression domain
- double-stranded DNA binding
- helix loop helix domain
- serine threonine rich domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- T-lymphoblastic leukemia/lymphoma
- diabetic nephropathy
- medulloblastoma
- brain cancer
- lack of spontaneous movement
role in cell
- expression in
- differentiation
- quantity
- formation
- number
- production
- growth
- development
- generation
- patterning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Olig2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- neuron fate commitment
- negative regulation of neuron differentiation
- spinal cord motor neuron differentiation
- myelination
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord oligodendrocyte cell fate specification
- thalamus development
- sensory organ development
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- identical protein binding
- protein binding
- protein dimerization activity
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity