CPEB1 Gene Summary [Human]

This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Details

Type
Retained Intron
Official Symbol
CPEB1
Official Name
cytoplasmic polyadenylation element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21744]
Ensembl ID
ENSG00000214575
Bio databases IDs NCBI: 64506 Ensembl: ENSG00000214575
Aliases cytoplasmic polyadenylation element binding protein 1
Synonyms CPEB, CPE-BP1, cytoplasmic polyadenylation element binding protein 1, h-CPEB, hCPEB-1, LOC107987415, mCPEB, mCpeb-1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPEB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ribonucleoprotein binding domain
  • RNA recognition motif (RRM) superfamily
  • Cytoplasmic polyadenylation element-binding protein ZZ domain
  • RNA recognition motif
  • mRNA binding
  • protein binding
  • aurora box
  • translation regulator
  • RNA binding
  • Leu-Asp-Ser-Arg motif
  • PEST domain
  • B-box-type zinc finger superfamily
  • mRNA 3' UTR binding
  • nucleic acid binding translation repressor
  • Cytoplasmic polyadenylation element-binding protein 1 N-terminus

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
regulated by
disease
  • schizophrenia
  • metastatic breast cancer
  • organismal death
  • lung metastasis
  • oligozoospermia
  • daytime sleepiness
  • pervasive developmental disorder
role in cell
  • apoptosis
  • phosphorylation in
  • expression in
  • proliferation
  • formation
  • synthesis in
  • motility
  • migration
  • invasion by
  • development

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • postsynaptic density (PSD) fractions
  • glutaminergic synapse
  • perinuclear region
  • postsynaptic region
  • cellular membrane
  • Nucleus
  • centrosome
  • cytosol
  • nucleoplasm
  • growth cone
  • synaptosomes
  • synapse
  • meiotic spindles
  • perikaryon
  • dendrites
  • postsynaptic density
  • excitatory synapses
  • cytoplasmic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CPEB1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cellular response to insulin stimulus
  • cellular response to amino acid stimulus
  • regulation of mRNA 3'-end processing
  • mRNA processing
  • cellular response to hypoxia
  • negative regulation of cytoplasmic translation
  • translation

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • postsynaptic density
  • nucleus
  • cytoplasm
  • membrane
  • cytosol
  • cytoplasmic mRNA processing body
  • synapse
  • neuron projection
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • mRNA 3'-UTR AU-rich region binding
  • metal ion binding
  • ribosome binding
  • translation repressor activity, nucleic acid binding
  • translation factor activity, nucleic acid binding
  • mRNA 3'-UTR binding

Gene-Specific Assays for Results You Can Trust

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