PSMD3 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | PSMD3 |
| Official Name | proteasome 26S subunit, non-ATPase 3 [Source:HGNC Symbol;Acc:HGNC:9560] |
| Ensembl ID | ENSG00000108344 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 3 |
| Synonyms | AntP91a, D11Bwg1349e, P58, proteasome 26S subunit, non-ATPase 3, proteasome (prosome, macropain) 26S subunit, non-ATPase, 3, Psd3, RPN3, S3, TSTA2, Tstap91a |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- protein binding
- Proteasome regulatory subunit C-terminal
Pathways
Biological processes and signaling networks where the PSMD3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- neoplasia
- sickle cell anemia
- lung cancer
- cardiovascular disorder
- lung squamous cell carcinoma
- squamous cell lung cancer
- allergic asthma
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- apoptosis
- expression in
- migration
- degradation in
- survival
- invasion by
- polyubiquitination in
- cell proliferation
- deubiquitination in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- basal bodies
- cytosol
- nucleoplasm
- cytoplasmic droplets
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- membrane
- cytosol
- proteasome accessory complex
- secretory granule lumen
- proteasome complex
- proteasome regulatory particle, lid subcomplex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme regulator activity