RPS28 Gene Summary [Human]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Details

Type
Retained Intron
Official Symbol
RPS28
Official Name
ribosomal protein S28 [Source:HGNC Symbol;Acc:HGNC:10418]
Ensembl ID
ENSG00000233927
Bio databases IDs NCBI: 6234 Ensembl: ENSG00000233927
Aliases ribosomal protein S28, 40S ribosomal protein S28
Synonyms DBA15, eS28, LOC684733, Ribosomal protein s28, S28
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • S1_like
  • structural constituent of ribosome
  • Ribosomal protein S28e
  • protein binding
  • RNA binding

Pathways

Biological processes and signaling networks where the RPS28 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Diamond-Blackfan anemia type 15 with mandibulofacial dysostosis
regulated by
  • TRL-CAG1
  • RPS28
  • SOD1
  • 5-fluorouracil
  • dihydrotestosterone
  • APH-1
  • LH
  • severe acute respiratory syndrome coronavirus 2
  • SPEN
  • CNOT6L
regulates
role in cell
  • cell death
  • processing in
  • translation in
  • biogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • interchromatin granule cluster fractions
  • pre-ribosome
  • ribosome
  • Nucleus
  • cytosol
  • nucleoplasm
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RPS28 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • maturation of SSU-rRNA
  • cytoplasmic translation
  • ribosomal small subunit biogenesis
  • ribosome biogenesis
  • ribosomal small subunit assembly
  • rRNA processing
  • translation

Cellular Component

Where in the cell the gene product is active
  • small-subunit processome
  • extracellular vesicular exosome
  • cytosolic small ribosomal subunit
  • cytoplasm
  • cytosol
  • small ribosomal subunit
  • synapse
  • nucleolus
  • ribosome
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding
  • structural constituent of ribosome

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.