Rps28 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; maturation of SSU-rRNA; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; hemolymphoid system; and vitelline vein. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps28 |
| Official Name | ribosomal protein S28 [Source:MGI Symbol;Acc:MGI:1859516] |
| Ensembl ID | ENSMUSG00000067288 |
| Bio databases IDs | |
| Aliases | ribosomal protein S28 |
| Synonyms | DBA15, eS28, LOC684733, Ribosomal protein s28, S28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- structural constituent of ribosome
- Ribosomal protein S28e
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rps28 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Diamond-Blackfan anemia type 15 with mandibulofacial dysostosis
regulates
- RPS28
- RNR
role in cell
- cell death
- processing in
- translation in
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pre-ribosome
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA
- cytoplasmic translation
- ribosomal small subunit biogenesis
- ribosome biogenesis
- ribosomal small subunit assembly
- rRNA processing
- translation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- extracellular vesicular exosome
- cytosolic small ribosomal subunit
- cytoplasm
- cytosol
- small ribosomal subunit
- synapse
- nucleolus
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome