ATG13
ATG13 Gene Summary
The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | ATG13 |
| Official Name | autophagy related 13 [Source:HGNC Symbol;Acc:HGNC:29091] |
| Ensembl ID | ENSG00000175224 |
| Bio databases IDs | |
| Aliases | autophagy related 13 |
| Synonyms | 1110053A20Rik,autophagy related 13,D2Ertd391e,Harbi1,Harbi1l,KIAA0652,PARATARG8,RGD1310685 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- protein kinase binding
- protein binding
- Autophagy-related protein 13
Pathways
Biological processes and signaling networks where the ATG13 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PLK1
- MAP1LC3C
- ULK1
- ATG101
- RPS28
- C9orf72
- RPS15
- RPL22
- NDN
- BRK1
disease
- neoplasia
- Alzheimer disease
- headache
- non-melanoma skin cancer
regulated by
- sirolimus
- MTOR
- Mef cells
- IFNG
- ESR1
- MAPK14
- OFD1
- leucine
- RPTOR
- MLST8
regulates
- RB1CC1
- ULK1
- ATG13
- AKT1S1
- MLST8
- RPTOR
- ULK2
- ATG9A
role in cell
- phosphorylation in
- proliferation
- autophagy in
- formation
- cell death
- binding in
- assembly
- autophagy by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ATG13 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of autophagy
- piecemeal microautophagy of nucleus
- protein localization to pre-autophagosomal structure
- negative regulation of cell proliferation
- macromitophagy
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- pre-autophagosomal structure membrane
- cytoplasm
- pre-autophagosomal structure
- mitochondrion
- cytosol
- autophagic vacuole
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase activator activity
- protein binding
- protein kinase regulator activity