PSMB9 Gene Summary [Human]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | PSMB9 |
| Official Name | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] |
| Ensembl ID | ENSG00000239836 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit beta 9 |
| Synonyms | Beta 1i, beta 1I IMMUNOPROTEASOME subunit, large multifunctional protease 2, LMP2, PRAAS3, PRAAS6, proteasome 20S subunit beta 9, proteasome 20S subunit β 9, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2), proteasome (prosome, macropain) subunit, β type 9 (large multifunctional peptidase 2), proteasome subunit X, Proteasome subunit, β type, 9, Psamb9, PSMB6i, RING12, β 1i, β 1I IMMUNOPROTEASOME subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMB9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- binding protein
- proteasome, beta subunit, bacterial type
- peptidase
- protein binding
- Proteasome subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- epithelial cancer
- cancer
- epithelial neoplasia
- neoplasia
- COVID-19
- non-insulin-dependent diabetes mellitus
- refractory multiple myeloma
- plasma cell myeloma
- relapsed multiple myeloma
role in cell
- quantity
- expression in
- activation
- number
- abnormal morphology
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMB9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of cysteine-type endopeptidase activity
- immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome core complex
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity