IGKV3-20
IGKV3-20 Gene Summary
Involved in antibacterial humoral response and glomerular filtration. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Variable Gene |
| Official Symbol | IGKV3-20 |
| Official Name | immunoglobulin kappa variable 3-20 [Source:HGNC Symbol;Acc:HGNC:5817] |
| Ensembl ID | ENSG00000239951 |
| Bio databases IDs | |
| Aliases | immunoglobulin kappa variable 3-20 |
| Synonyms | 13K18,A27,immunoglobulin kappa variable 3-20,immunoglobulin κ variable 3-20 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cdr3 domain
Pathways
Biological processes and signaling networks where the IGKV3-20 gene plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- B Cell Development
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- FcγRIIB Signaling in B Lymphocytes
- IL-15 Signaling
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- Protein l
- FANCD2
- FN1
- MYC
- BAG1
- IGHV4-39
- cofilin
- FOXA1
- FOXO1
- IGHV3-21
disease
regulated by
- methylprednisolone
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IGKV3-20 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- immune response
- glomerular filtration
- adaptive immune response
- antibacterial humoral response
- immunoglobulin production
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory IgA immunoglobulin complex
- blood microparticle
- extracellular region
- monomeric IgA immunoglobulin complex
- pentameric IgM immunoglobulin complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- antigen binding