SNHG1 Gene Summary [Human]
This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]
Details
| Type | Retained Intron |
| Official Symbol | SNHG1 |
| Official Name | small nucleolar RNA host gene 1 [Source:HGNC Symbol;Acc:HGNC:32688] |
| Ensembl ID | ENSG00000255717 |
| Bio databases IDs | |
| Aliases | small nucleolar RNA host gene 1, U22 snoRNA host gene, non-protein coding RNA 57, long intergenic non-protein coding RNA 57 |
| Synonyms | LINC00057, lncRNA16, NCRNA00057, small nucleolar RNA host gene 1, U22HG, UHG |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- epithelial cancer
- relapsing-remitting multiple sclerosis
- hepatocellular carcinoma
- liver cancer
- lung cancer
- organismal death
- hepatoblastoma
- nonobstructive azoospermia
role in cell
- downregulation in
- accumulation in
- apoptosis
- expression in
- binding in
- differentiation
- growth
- colony formation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNHG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleolus